
Blue Cross Blue Shield (BCBS) coverage for genetic testing services varies depending on the specific plan and provider network. BCBS covers genetic testing for certain conditions, such as inherited disorders like sickle cell anemia and cystic fibrosis.
BCBS may require prior authorization for some genetic tests, which can take several days to process. This is to ensure the test is medically necessary and aligns with treatment guidelines.
BCBS covers genetic testing for BRCA1 and BRCA2 mutations, which are associated with an increased risk of breast and ovarian cancer. Some plans may also cover genetic testing for other cancers, such as colon and prostate cancer.
Genetic testing may be covered for individuals with a family history of a genetic disorder or for those with a personal history of cancer. However, coverage may vary depending on the specific plan and provider network.
What BCBS Covers
BCBS covers genetic testing that meets the General Genetic Testing Criteria, including BRCA testing.

Genetic testing for BRCA is covered by BCBS when the requirements for General Genetic Testing Criteria are met.
BCBS covers genetic testing that meets specific criteria, which means you'll need to review your individual plan to see what's included.
BRCA testing is a type of genetic testing that's covered by BCBS when it meets the General Genetic Testing Criteria.
BCBS coverage for genetic testing varies depending on the specific test and your individual plan, so be sure to check your policy for details.
Requirements and Process
To get genetic testing covered by BCBS, you'll need to meet certain requirements. Prior authorization is a must, and requests should include documentation that shows how the testing aligns with BCBS's policy.
Here's a breakdown of the necessary information to include in your prior authorization request:
- Recommendations from a licensed genetic counselor or ordering provider,
- Clinical findings including family history and any previous test results,
- A description of how the genetic test results will differentiate between treatment options for the member or meet the requirements of 2.a or 2.b,
- The rationale for choosing the particular type of genetic test requested (e.g., full gene sequencing, deletion/duplication, microarray, individual variants), and
- Medical literature citations as applicable.
Prior Authorization Requirements
Prior Authorization Requirements are a crucial step in the genetic testing process.
Genetic testing requires prior authorization, which involves submitting a request with specific documentation. This documentation must include recommendations from a licensed genetic counselor or ordering provider, as well as clinical findings like family history and previous test results.

To meet the requirements, your request must also include a description of how the genetic test results will differentiate between treatment options for the member. This is a key consideration, as it ensures that the testing is being used to inform treatment decisions.
You'll also need to provide the rationale for choosing the particular type of genetic test requested. This might involve explaining why full gene sequencing, deletion/duplication, microarray, or individual variants are the most appropriate tests for the patient.
Here are the specific requirements for prior authorization requests:
- Recommendations from a licensed genetic counselor or ordering provider
- Clinical findings including family history and any previous test results
- A description of how the genetic test results will differentiate between treatment options for the member
- The rationale for choosing the particular type of genetic test requested
- Medical literature citations as applicable
By following these requirements, you can ensure that your prior authorization request is complete and meets the necessary criteria.
Genetic Counseling Requirement
Genetic counseling is a crucial step before genetic testing can be conducted. A licensed genetic counselor or the ordering provider must counsel the member about the medical treatment options prior to the genetic test being conducted.
This requirement is in place to ensure that patients understand the implications of genetic testing and can make informed decisions about their care.

Genetic counseling is typically done in person or over the phone, and it's a chance for patients to ask questions and get a better understanding of the testing process.
A licensed genetic counselor will discuss the risks and benefits of the test, as well as any potential treatment options that may be available.
This counseling session is usually done before the genetic test is ordered, and it's an important step in the process.
Specific Tests and Coverage
Genetic testing and counseling are considered medically necessary for infants and children with significant developmental delays whose cause remains undetermined through routine testing.
Chromosomal Microarray (CMA) and chromosomal testing for Fragile X are the specific genetic tests that may be covered in such cases.
Genetic testing is limited to these two tests, as per the medical necessity guidelines.
Brca Testing Coverage
BRCA testing coverage is available under specific circumstances.
BRCA testing is covered when the requirements from General Genetic Testing Criteria are met.
This means that you'll need to meet certain criteria before the test is approved.
Pharmacogenetic Testing

Pharmacogenetic Testing is a covered benefit in the state, specifically for Cyp2d6 gene testing.
Senate Bill 1726 passed in May, adding this benefit to the state's healthcare budget.
Rapid whole-genome sequencing is now covered for pediatric Medicaid patients who meet certain clinical criteria, thanks to the state's current healthcare budget.
Genetic Testing Not Covered
Genetic testing is not covered under certain circumstances. These include determining specific diagnoses or syndromes when such diagnoses would not definitively alter medical treatment.
Genetic testing is often used to determine the likelihood of associated medical conditions occurring in the future, but this is not a covered reason.
The test is not a substitute for ongoing monitoring or testing of potential complications or sequelae of a suspected genetic anomaly.
Genetic testing is also not used for determining current or future reproductive decisions.
Paying for panels or batteries of tests that include one or more medically necessary tests, along with tests that are not medically necessary, is not covered when the medically necessary tests are available individually.

Some examples of when genetic testing is not covered include:
Determining specific diagnoses or syndromes when such diagnoses would not definitively alter the medical treatment of the member.Determining the likelihood of associated medical conditions occurring in the future.As a substitute for ongoing monitoring or testing of potential complications or sequelae of a suspected genetic anomaly.For purposes of determining current or future reproductive decisions.For determining eligibility for a clinical trial.Paying for panels or batteries of tests that include one or more medically necessary tests, along with tests that are not medically necessary, when the medically necessary tests are available individually.
Impact on Care
Genetic testing can have a significant impact on the care and treatment of individuals with genetic disorders. This is because genetic testing can identify genetic mutations that can cause or contribute to certain health conditions.
BCBS may cover genetic testing for certain conditions, such as BRCA1 and BRCA2 gene mutations, which increase the risk of breast and ovarian cancer.

Genetic testing can also help identify genetic variants that may affect an individual's response to certain medications. BCBS may cover genetic testing to guide treatment decisions for patients with conditions such as warfarin sensitivity.
Genetic testing can provide important information for individuals and families affected by genetic disorders, allowing them to make informed decisions about their care and treatment.
Sources
- https://news.blueshieldca.com/2018/11/19/genetic-testing
- https://providers.bcbsal.org/portal/resources/-/resource/viewArticle/TBUFOONPGI
- https://www.facingourrisk.org/privacy-policy-legal/laws-protections/ACA/screening-preventive-services/genetic-counseling-testing
- https://www.acog.org/advocacy/policy-priorities/non-invasive-prenatal-testing/payer-coverage-overview
- https://geneticspolicy.nccrcg.org/medicaid-policy/arizona/
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